Edition 7.6 6.1308

Martin and S. Moll were responsible for concept and design. Martin, S. Moll, J. Beyer-Westendorf, B. Davidson, M. Huisman, and P. Sandset were responsible for interpretation of data, critical writing or revision of the intellectual content, and final approval of the version to be published. Disclosure of Conflict of Interests.

Davidson reports personal fees from Bayer, outside the submitted work. The other authors state that they have no conflict of interest. Supporting Information. Additional Supporting Information may be found in the online version of this article:.

National Center for Biotechnology Information , U. J Thromb Haemost. Author manuscript; available in PMC Jun 1. Author information Copyright and License information Disclaimer. Copyright notice. The publisher's final edited version of this article is available free at J Thromb Haemost. See other articles in PMC that cite the published article. Associated Data Supplementary Materials Fig.

Table S1. Table S1B. Table S1C. Table S1D. Table S2. Introduction Four direct-acting oral anticoagulants DOACs — the thrombin inhibitor dabigatran, and the activated factor X FXa inhibitors apixaban, edoxaban, and rivaroxaban —are approved in many countries for the treatment of venous thromboembolism VTE , the prevention of VTE after hip and knee arthroplasty, and ischemic stroke prevention in patients with non-valvular atrial fibrillation AF.

Evidence on the efficacy of VTE treatment and stroke prevention in AF No large randomized controlled trial has specifically investigated the efficacy and safety of DOACs in the obese population. Table 1 Weight categories and number of obese patients in major phase III trials.

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